The Science Behind Gray Labs
We don't run our own trials.
We show you the ones that matter.
Every active ingredient in the Gray Labs system has been evaluated in peer-reviewed, published research. Below is the full index — studies linked, dosages explained, nothing hidden.
01 · Our Philosophy
Ingredient-first.
Honest by design.
"The supplement is the accelerant, not the shortcut. The science tells you what your body needs — the lifestyle is what makes it work."
Gray Labs does not claim to have conducted its own randomised controlled trials. We formulate around ingredients that already have extensive published evidence — the same approach used by the most credible brands in the longevity category. We cite the studies. We show the dosages. We let the research speak.
One thing we will never do: present category-level ingredient science as evidence specific to Gray Labs products. "NMN has been studied in 200+ published papers" is honest. "Gray Labs Male+ is clinically proven" would not be — and we will not say it.
Dosage Matters
We publish the doses in our formulas. An ingredient at 50mg is not the same as one at 300mg. Hiding dosages is how brands practice clinical dusting — inclusion without effect.
Mechanism Over Promise
We describe what each ingredient does at the cellular level — not how you will feel. How you feel is the outcome of a thousand variables. The mechanism is what the evidence supports.
Lifestyle Is Part of the Formula
The studies behind these ingredients often involved subjects who also exercised and ate well. Per FTC guidance, we disclose that. The supplement works best alongside the life it supports.
02 · The Ingredient Index
Three products.
Every ingredient explained.
Each table lists the active ingredient, its cellular mechanism, what the published research actually supports, and direct links to the peer-reviewed studies. Citations go to PubMed or published journal DOIs — not blog posts or marketing pages.
Select a product below to explore its full ingredient profile.
The cellular energy foundation of the Gray Labs system. NAD+ is the coenzyme required for mitochondrial function, DNA repair, and sirtuin activation. By age 50, NAD+ levels have declined approximately 50% from peak.
← Scroll to explore →
| Ingredient | Mechanism | What the research supports | Key studies |
|---|---|---|---|
| Nicotinamide Riboside | NAD+ precursor. Supports healthy NAD+ levels in blood and tissues. | Oral NR supplementation has been shown to increase whole-blood NAD+ metabolites in healthy adults. Human RCTs demonstrate measurable biomarker changes at doses of 250–500mg. | |
| Resveratrol (trans-)Standardised extract | SIRT1 activator. Supports healthy cardiovascular function and cellular longevity pathways. | Trans-resveratrol has been studied for its role in sirtuin activation. Human trials at 150–500mg show measurable effects on metabolic and cardiovascular biomarkers alongside a healthy lifestyle. | |
| Vitamin D350 mcg (2,000 IU) · Cholecalciferol | Essential cofactor for NAD+ metabolism. Supports calcium absorption, immune resilience, and cellular energy conversion. | Our approach is a game-changer in NAD+ metabolism. Most companies skip it — we don't. Without Vitamin D, NR conversion is less effective. We include it to maximise absorption, boost resilience, and power real results. |
Designed to support healthy testosterone levels, muscle recovery, and the hormonal foundations that matter after 40. Male+ is formulated to work alongside regular physical activity. The supplement supports the work; it does not replace it.
← Scroll to explore →
| Ingredient | Mechanism | What the research supports | Key studies |
|---|---|---|---|
| ZincZinc gluconate · high bioavailability form | Essential cofactor for testosterone synthesis and immune function. | Zinc has a documented role in testosterone synthesis and immune regulation. Supplementation in zinc-deficient adults supports healthy levels within the normal range. | |
| KSM-66 AshwagandhaFull-spectrum root extract | Supports healthy testosterone levels and cortisol regulation in adult men. | KSM-66 has been evaluated in double-blind, placebo-controlled trials for its effects on serum testosterone, cortisol, and body composition in resistance-trained men. | |
| Fenugreek ExtractStandardised for furostanolic saponins | Supports healthy hormone balance and male vitality. | Fenugreek has been evaluated in RCTs for its effects on testosterone levels and sexual health markers in adult men alongside resistance training. | |
| Saw Palmetto ExtractSerenoa repens · 200mg | 5-alpha-reductase modulator. Supports healthy DHT metabolism and prostate-related hormonal balance in men. | Human tissue studies show saw palmetto extract shifts testosterone and DHT concentrations in the prostate, consistent with 5-alpha-reductase inhibition. A 12-week trial using a phytosterol-enriched extract showed favourable changes in androgen-related symptom scores versus placebo in men aged 40–65. | |
| DHEADehydroepiandrosterone · 25mg | Adrenal hormone precursor. Supports healthy testosterone synthesis in older adults. | DHEA declines significantly with age. Human research supports its role as a precursor in healthy testosterone and oestrogen metabolism — not as a hormone replacement. | |
| BoronBoron citrate · 1.5mg | Trace mineral cofactor. Supports healthy free testosterone and SHBG balance. | A human trial found one week of boron supplementation significantly increased free testosterone and decreased SHBG and estradiol in healthy men. Broader review literature supports boron's role in steroid hormone regulation. |
Formulated for the hormonal, mood, and stress-related shifts that occur in women after 40 — combining a mineral foundation with adaptogenic botanicals traditionally used for balance, calm, and vitality. Best results alongside regular movement, adequate sleep, and stress management.
← Scroll to explore →
| Ingredient | Mechanism | What the research supports | Key studies |
|---|---|---|---|
| MagnesiumMagnesium citrate · 40mg | Essential mineral cofactor. Supports metabolic function, muscle relaxation, and healthy stress response. | Human RCTs show magnesium supplementation supports stress reduction, particularly alongside vitamin B6, in adults with elevated baseline stress. | |
| Diindolylmethane (DIM)275mg | Supports healthy estrogen metabolism balance (2-OH:16-OH pathway). | Human trials show DIM shifts the ratio of estrogen metabolites and increases SHBG. | |
| Maca Root ExtractLepidium meyenii · 250mg | Traditional adaptogen. Supports mood and sexual wellness independent of direct hormonal activity. | RCTs in peri/postmenopausal women show improved psychological and sexual-function symptom scores, with effects not linked to changes in estrogen or androgen levels. | |
| Damiana ExtractTurnera aphrodisiaca · 150mg | Traditionally used botanical; laboratory studies show mild aromatase- and MAO-B–inhibiting activity. | Evidence for Damiana is primarily mechanistic and preclinical rather than large human RCTs — an area we're transparent about rather than overstate. | |
| Siberian GinsengEleutherococcus senticosus · 150mg | Traditional adaptogen studied for stress and fatigue support. | Human RCTs show Siberian ginseng supplementation can improve endurance capacity and cardiovascular response to exertion, with a good overall safety profile; findings on fatigue specifically have been more mixed. | |
| Oat Straw PowderAvena sativa · 100mg | Supports cognitive function and stress response. | RCTs in healthy adults aged 35–65 show improved working memory and a reduced physiological stress response with green oat extract. | |
| Passionflower ExtractStd. to contain 5% flavones · 100mg | Traditional calming botanical. | RCTs show short-term improvements in subjective sleep quality in healthy adults, and a clinical trial found passionflower extract performed comparably to a standard anti-anxiety medication for generalized anxiety symptoms. |
03 · Manufacturing & Quality
Made to pharmaceutical standards.
The FDA does not "approve" dietary supplements — any brand that claims FDA approval is either confused or misleading. The correct standard is cGMP: the same quality protocols used by pharmaceutical manufacturers. Every Gray Labs product is made in an FDA-registered, cGMP-compliant facility in the United States.
FDA-Registered Facility
Manufactured in a facility registered with the U.S. Food and Drug Administration, compliant with 21 CFR Part 111.
cGMP Compliant
Current Good Manufacturing Practice governs every stage: raw material testing, in-process controls, finished-product testing, and full batch record documentation.
Made in the United States
Formulated, manufactured, and fulfilled from the U.S. Domestic production means tighter supply chain oversight and faster quality intervention.
Third-Party Testing
Products are tested for label accuracy, contaminants, and microbiological safety. NSF Certified for Sport certification is in progress.
04 · Frequently Asked
Questions worth asking.
Transparency is part of the product. If you have a question the FAQ doesn't answer, email us at support@graylaboratories.com and we'll respond within one business day.
Why don't you run your own clinical trials?
Because the ingredients inside our formulas already have extensive published human research — conducted by independent academic institutions with no commercial interest in the outcome. We chose to formulate around what the science already knows, cite the sources, and let you decide.
What does "clinically-studied ingredient" actually mean?
It means the ingredient — not the finished Gray Labs product — has been evaluated in controlled human trials published in peer-reviewed journals. "Clinically-studied ingredient" is accurate. "Clinically proven product" would not be — and we will not claim it.
How do you choose dosages?
We formulate at doses consistent with the ranges used in published human trials — not at "clinical dusting" levels that allow ingredient inclusion on the label without meaningful effect.
Is NAD+ supplementation safe long-term?
Nicotinamide Riboside (NR) has been studied in human trials up to 12 months with no significant adverse events at standard doses, with 40+ human clinical trials on record. If you are on prescription medication or managing a chronic condition, consult your physician before use.
When will I notice a difference?
Cellular change is not the same as felt change. NAD+ biomarker levels respond within weeks of consistent supplementation — but the downstream effects compound over 60–90 days. This is why we offer a 90-day guarantee rather than 30.
Is Female+ safe to take alongside HRT?
Female+ contains herbal adaptogens and micronutrients, not hormones. If you are on hormone replacement therapy or any prescription medication, please consult your physician or pharmacist before adding Female+ to your regimen.
These statements have not been evaluated by the Food and Drug Administration. Gray Labs products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. For best results, combine with regular physical activity, quality sleep, and balanced nutrition. If you are pregnant, nursing, taking prescription medication, or managing a medical condition, consult your physician before use.