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Men vs Women: The Biology of Aging After 50

Men vs Women: The Biology of Aging After 50

Men don’t go through menopause. Women don’t deal with testosterone decline. So why are they sold the same “one-size-fits-all” supplements?


Why Men and Women Age Differently After 50

Aging is universal, but the biology behind it isn’t. After 50, men and women experience distinct hormonal and metabolic changes that reshape health, energy, and performance.

Women

Menopause drives shifts in estrogen that influence bone density, fat storage, metabolism, sleep, and cognitive clarity.

Men

Testosterone typically declines gradually, affecting lean muscle, recovery, motivation, and day-to-day vitality.

Bottom line: biology diverges in important ways—so support should, too.

The Limits of “One-Size-Fits-All” Supplements

  • Women: During and after menopause, bone turnover can accelerate and metabolism can shift.
  • Men: A steady slide in testosterone may pair with stress-related imbalances (e.g., elevated cortisol).

Generic formulas may help broadly, but they rarely address the distinct pathways that matter most for each sex after 50.

The Role of NAD+ in Aging

NAD+ supports cellular energy and maintenance. It’s a powerful foundation—but not the whole plan.

  • For women: support aligned to menopause-related changes can help maintain bone health, metabolic balance, and clarity.
  • For men: targeted support for testosterone health, muscle resilience, and recovery becomes increasingly valuable.

Aging is cellular—and it’s also gender-specific.

The GrayLabs Approach

GrayLabs was built on one truth: men and women age differently, so their supplements should too. Our modular system lets you build on a cellular foundation and add targeted support:

  • Core NAD+™ — a foundation for cellular energy, focus, and repair.
  • Male+™ — designed to support testosterone health, stress balance, and muscle recovery.
  • Female+™ — created to support women navigating menopause and beyond.

Explore GrayLabs


Rethinking Aging After 50

Aging isn’t something to fear—it’s something to manage with intention. Understanding the different biological realities of men and women after 50 helps you make smarter choices around energy, strength, and focus for the years ahead.

Quick Answers

Do men and women age differently after 50?

Yes. Menopause and testosterone decline reflect different hormonal pathways that can influence bone, metabolism, muscle, recovery, and clarity.

Is NAD+ alone enough?

NAD+ supports cellular energy and maintenance. Comprehensive support often considers sex-specific needs, such as menopause-related changes in women and testosterone health in men.